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| RND | DATE | TIME | VENUE/COURT | HOME TEAM | AWAY TEAM | ||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 16/04/21 (Fri) | 12:00 | Swinburne Centre | 13.17-95 | Richmond | vs | Sandringham | 7.13-55 | View |
| 16/04/21 (Fri) | 19:30 | SkyBus Stadium | 20.6-126 | Frankston | vs | Coburg | 14.12-96 | View | |
| 17/04/21 (Sat) | 11:20 | Victoria University Whitten Oval | 16.13-109 | Footscray Bulldogs | vs | Gold Coast Suns | 6.6-42 | View | |
| 17/04/21 (Sat) | 12:00 | Moreton Bay Sports Complex | 15.14-104 | Brisbane Lions | vs | Essendon Bombers | 5.7-37 | View | |
| 17/04/21 (Sat) | 12:00 | Tramway Oval | 15.6-96 | Sydney Swans | vs | GWS Giants | 10.10-70 | View | |
| 17/04/21 (Sat) | 13:00 | Graham Road, QLD | 20.13-133 | Aspley | vs | Port Melbourne | 12.8-80 | View | |
| 17/04/21 (Sat) | 14:00 | IKON Park | 16.12-108 | Carlton | vs | Southport | 17.7-109 | View | |
| 17/04/21 (Sat) | 14:30 | Avalon Airport Oval (Chirnside Park) | 9.8-62 | Werribee | vs | Collingwood | 10.9-69 | View | |
| 18/04/21 (Sun) | 12:05 | Box Hill City Oval | 10.7-67 | Box Hill Hawks | vs | Casey Demons | 17.16-118 | View | |
| 18/04/21 (Sun) | 13:00 | GMHBA Stadium | 18.15-123 | Geelong Cats | vs | North Melbourne | 6.8-44 | View | |
| 18/04/21 (Sun) | 13:00 | Preston City Oval | 6.11-47 | Northern Bullants | vs | Williamstown | 14.15-99 | View | |
| 2 | 22/04/21 (Thu) | 19:15 | Blacktown Olympic Park | 10.3-63 | GWS Giants | vs | Footscray Bulldogs | 21.9-135 | View |
| 24/04/21 (Sat) | 09:45 | Metricon Stadium | 14.11-95 | Gold Coast Suns | vs | Sydney Swans | 12.9-81 | View | |
| 24/04/21 (Sat) | 11:00 | IKON Park | 24.10-154 | Carlton | vs | Brisbane Lions | 13.7-85 | View | |
| 24/04/21 (Sat) | 13:00 | Arden St - North Melbourne | 5.9-39 | North Melbourne | vs | Frankston | 16.8-104 | View | |
| 24/04/21 (Sat) | 13:00 | Fankhauser Reserve | 14.25-109 | Southport | vs | Aspley | 15.5-95 | View | |
| 24/04/21 (Sat) | 14:00 | Box Hill City Oval | 17.10-112 | Box Hill Hawks | vs | Northern Bullants | 8.8-56 | View | |
| 24/04/21 (Sat) | 14:00 | Swinburne Centre | 5.7-37 | Richmond | vs | Casey Demons | 13.18-96 | View | |
| 24/04/21 (Sat) | 14:00 | Victoria Park | 6.14-50 | Collingwood | vs | Essendon Bombers | 12.13-85 | View | |
| 24/04/21 (Sat) | 14:30 | ETU Stadium | 13.14-92 | Port Melbourne | vs | Sandringham | 9.11-65 | View | |
| 24/04/21 (Sat) | 19:00 | Avalon Airport Oval (Chirnside Park) | 7.11-53 | Werribee | vs | Williamstown | 9.10-64 | View | |
| 25/04/21 (Sun) | BYE | BYE | Geelong Cats | ||||||
| 25/04/21 (Sun) | BYE | BYE | Coburg | ||||||
| 3 | 29/04/21 (Thu) | 19:10 | Marvel Stadium | 3.6-24 | North Melbourne | vs | Casey Demons | 19.17-131 | View |
| 30/04/21 (Fri) | 16:00 | Olympic Park Oval | 9.12-66 | Collingwood | vs | Gold Coast Suns | 9.8-62 | View | |
| 01/05/21 (Sat) | 13:05 | Preston City Oval | 6.11-47 | Northern Bullants | vs | Footscray Bulldogs | 12.18-90 | View | |
| 01/05/21 (Sat) | 14:05 | Avalon Airport Oval (Chirnside Park) | 18.16-124 | Werribee | vs | Richmond | 6.7-43 | View | |
| 01/05/21 (Sat) | 14:35 | Tramway Oval | 8.12-60 | Sydney Swans | vs | Geelong Cats | 9.10-64 | View | |
| 01/05/21 (Sat) | 19:00 | SkyBus Stadium | 13.14-92 | Frankston | vs | Aspley | 10.11-71 | View | |
| 01/05/21 (Sat) | 19:10 | Downer Oval | 15.17-107 | Williamstown | vs | Port Melbourne | 10.9-69 | View | |
| 02/05/21 (Sun) | 12:00 | South Pine Sport Complex | 8.7-55 | Brisbane Lions | vs | Coburg | 9.19-73 | View | |
| 02/05/21 (Sun) | 12:05 | Blacktown Olympic Park | 14.10-94 | GWS Giants | vs | Southport | 8.16-64 | View | |
| 02/05/21 (Sun) | 12:05 | Windy Hill | 8.4-52 | Essendon Bombers | vs | Carlton | 14.17-101 | View | |
| 02/05/21 (Sun) | 14:30 | Wilson Storage Trevor Barker Beach Oval | 15.8-98 | Sandringham | vs | Box Hill Hawks | 19.14-128 | View | |
| 4 | 06/05/21 (Thu) | 19:10 | Marvel Stadium | 17.15-117 | Geelong Cats | vs | Northern Bullants | 11.6-72 | View |
| 08/05/21 (Sat) | 12:05 | Victoria Park | 14.11-95 | Collingwood | vs | Coburg | 13.13-91 | View | |
| 08/05/21 (Sat) | 13:35 | Downer Oval | 17.13-115 | Williamstown | vs | Frankston | 4.7-31 | View | |
| 08/05/21 (Sat) | 14:00 | Fankhauser Reserve | 24.9-153 | Southport | vs | North Melbourne | 7.4-46 | View | |
| 08/05/21 (Sat) | 14:35 | Box Hill City Oval | 8.5-53 | Box Hill Hawks | vs | Werribee | 13.12-90 | View | |
| 09/05/21 (Sun) | BYE | BYE | Casey Demons | ||||||
| 09/05/21 (Sun) | 12:05 | Victoria University Whitten Oval | 11.11-77 | Footscray Bulldogs | vs | Carlton | 8.11-59 | View | |
| 09/05/21 (Sun) | BYE | BYE | Sandringham | ||||||
| 09/05/21 (Sun) | BYE | BYE | Brisbane Lions | ||||||
| 09/05/21 (Sun) | BYE | BYE | Port Melbourne | ||||||
| 09/05/21 (Sun) | BYE | BYE | Gold Coast Suns | ||||||
| 09/05/21 (Sun) | BYE | BYE | Sydney Swans | ||||||
| 09/05/21 (Sun) | BYE | BYE | Richmond | ||||||
| 09/05/21 (Sun) | BYE | BYE | GWS Giants | ||||||
| 09/05/21 (Sun) | BYE | BYE | Aspley | ||||||
| 09/05/21 (Sun) | BYE | BYE | Essendon Bombers | ||||||
| 5 | 13/05/21 (Thu) | 19:10 | Metricon Stadium | 8.13-61 | Gold Coast Suns | vs | Brisbane Lions | 19.7-121 | View |
| 15/05/21 (Sat) | 12:05 | Graham Road, QLD | 7.5-47 | Aspley | vs | Southport | 23.18-156 | View | |
| 15/05/21 (Sat) | 14:00 | Casey Fields | 7.15-57 | Casey Demons | vs | Geelong Cats | 8.8-56 | View | |
| 15/05/21 (Sat) | 14:00 | ETU Stadium | 7.11-53 | Port Melbourne | vs | Coburg | 12.17-89 | View | |
| 15/05/21 (Sat) | 14:30 | Wilson Storage Trevor Barker Beach Oval | 13.9-87 | Sandringham | vs | Williamstown | 11.12-78 | View | |
| 15/05/21 (Sat) | 14:35 | Swinburne Centre | 19.9-123 | Richmond | vs | GWS Giants | 3.8-26 | View | |
| 15/05/21 (Sat) | 16:45 | Sydney Cricket Ground (SCG) | 12.14-86 | Sydney Swans | vs | Collingwood | 8.5-53 | View | |
| 16/05/21 (Sun) | 12:05 | Box Hill City Oval | 23.12-150 | Box Hill Hawks | vs | North Melbourne | 6.6-42 | View | |
| 16/05/21 (Sun) | BYE | BYE | Northern Bullants | ||||||
| 16/05/21 (Sun) | BYE | BYE | Carlton | ||||||
| 16/05/21 (Sun) | BYE | BYE | Footscray Bulldogs | ||||||
| 16/05/21 (Sun) | BYE | BYE | Werribee | ||||||
| 16/05/21 (Sun) | 14:05 | Windy Hill | 12.11-83 | Essendon Bombers | vs | Frankston | 10.8-68 | View | |
| 6 | 20/05/21 (Thu) | 19:10 | GMHBA Stadium | 15.15-105 | Geelong Cats | vs | Coburg | 7.6-48 | View |
| 21/05/21 (Fri) | 19:00 | Fankhauser Reserve | 17.14-116 | Southport | vs | Gold Coast Suns | 5.3-33 | View | |
| 21/05/21 (Fri) | 19:30 | SkyBus Stadium | 5.17-47 | Frankston | vs | Footscray Bulldogs | 19.14-128 | View | |
| 22/05/21 (Sat) | 11:35 | Gabba | 12.8-80 | Brisbane Lions | vs | Richmond | 21.16-142 | View | |
| 22/05/21 (Sat) | 12:05 | Blacktown Olympic Park | 11.9-75 | GWS Giants | vs | Port Melbourne | 9.12-66 | View | |
| 22/05/21 (Sat) | 13:30 | Graham Road, QLD | 12.10-82 | Aspley | vs | Sandringham | 14.9-93 | View | |
| 22/05/21 (Sat) | 14:05 | Windy Hill | 11.4-70 | Essendon Bombers | vs | North Melbourne | 12.13-85 | View | |
| 23/05/21 (Sun) | 12:00 | IKON Park | 6.10-46 | Carlton | vs | Box Hill Hawks | 19.16-130 | View | |
| 23/05/21 (Sun) | 13:00 | Casey Fields | 12.13-85 | Casey Demons | vs | Sydney Swans | 6.9-45 | View | |
| 23/05/21 (Sun) | BYE | BYE | Collingwood | ||||||
| 23/05/21 (Sun) | BYE | BYE | Williamstown | ||||||
| 23/05/21 (Sun) | 14:05 | Preston City Oval | 3.5-23 | Northern Bullants | vs | Werribee | 27.21-183 | View | |
| 7 | 27/05/21 (Thu) | 19:10 | SkyBus Stadium | Frankston | vs | Richmond | View | ||
| 29/05/21 (Sat) | 10:05 | Moreton Bay Sports Complex | Brisbane Lions | vs | GWS Giants | View | |||
| 29/05/21 (Sat) | 12:00 | Arden St - North Melbourne | North Melbourne | vs | Coburg | View | |||
| 29/05/21 (Sat) | 13:00 | Avalon Airport Oval (Chirnside Park) | Werribee | vs | Sandringham | View | |||
| 29/05/21 (Sat) | 13:30 | Fankhauser Reserve | Southport | vs | Northern Bullants | View | |||
| 29/05/21 (Sat) | 13:30 | Metricon Stadium | Gold Coast Suns | vs | Aspley | View | |||
| 29/05/21 (Sat) | 14:05 | Box Hill City Oval | Box Hill Hawks | vs | Port Melbourne | View | |||
| 29/05/21 (Sat) | 16:55 | Melbourne Cricket Ground | Collingwood | vs | Geelong Cats | View | |||
| 30/05/21 (Sun) | 11:30 | Sydney Cricket Ground (SCG) | Sydney Swans | vs | Carlton | View | |||
| 30/05/21 (Sun) | 12:00 | Victoria University Whitten Oval | Footscray Bulldogs | vs | Casey Demons | View | |||
| 30/05/21 (Sun) | 14:00 | Downer Oval | Williamstown | vs | Essendon Bombers | View | |||
| 8 | 05/06/21 (Sat) | 10:05 | Tramway Oval | 10.13-73 | Sydney Swans | vs | Southport | 12.16-88 | View |
| 05/06/21 (Sat) | 13:05 | Graham Road, QLD | 14.13-97 | Aspley | vs | Brisbane Lions | 14.14-98 | View | |
| 06/06/21 (Sun) | BYE | BYE | Northern Bullants | ||||||
| 06/06/21 (Sun) | BYE | BYE | Casey Demons | ||||||
| 06/06/21 (Sun) | BYE | BYE | GWS Giants | ||||||
| 06/06/21 (Sun) | BYE | BYE | Coburg | ||||||
| 06/06/21 (Sun) | BYE | BYE | Frankston | ||||||
| 06/06/21 (Sun) | BYE | BYE | Gold Coast Suns | ||||||
| 06/06/21 (Sun) | BYE | BYE | Richmond | ||||||
| 06/06/21 (Sun) | BYE | BYE | North Melbourne | ||||||
| 06/06/21 (Sun) | BYE | BYE | Werribee | ||||||
| 06/06/21 (Sun) | BYE | BYE | Williamstown | ||||||
| 06/06/21 (Sun) | BYE | BYE | Footscray Bulldogs | ||||||
| 06/06/21 (Sun) | BYE | BYE | Carlton | ||||||
| 06/06/21 (Sun) | BYE | BYE | Collingwood | ||||||
| 06/06/21 (Sun) | BYE | BYE | Geelong Cats | ||||||
| 06/06/21 (Sun) | BYE | BYE | Richmond | ||||||
| 06/06/21 (Sun) | BYE | BYE | Essendon Bombers | ||||||
| 06/06/21 (Sun) | BYE | BYE | Sandringham | ||||||
| 06/06/21 (Sun) | BYE | BYE | Port Melbourne | ||||||
| 9 | 12/06/21 (Sat) | 11:05 | Tramway Oval | 16.8-104 | Sydney Swans | vs | Gold Coast Suns | 17.5-107 | View |
| 12/06/21 (Sat) | 12:05 | Blacktown Olympic Park | 17.12-114 | GWS Giants | vs | Aspley | 9.11-65 | View | |
| 12/06/21 (Sat) | BYE | BYE | Richmond | ||||||
| 12/06/21 (Sat) | BYE | BYE | Essendon Bombers | ||||||
| 12/06/21 (Sat) | BYE | BYE | Carlton | ||||||
| 12/06/21 (Sat) | BYE | BYE | Frankston | ||||||
| 12/06/21 (Sat) | BYE | BYE | Brisbane Lions | ||||||
| 12/06/21 (Sat) | BYE | BYE | Footscray Bulldogs | ||||||
| 12/06/21 (Sat) | BYE | BYE | Northern Bullants | ||||||
| 12/06/21 (Sat) | BYE | BYE | Southport | ||||||
| 12/06/21 (Sat) | BYE | BYE | Werribee | ||||||
| 12/06/21 (Sat) | BYE | BYE | Williamstown | ||||||
| 13/06/21 (Sun) | BYE | BYE | Port Melbourne | ||||||
| 13/06/21 (Sun) | BYE | BYE | Sandringham | ||||||
| 13/06/21 (Sun) | BYE | BYE | Casey Demons | ||||||
| 10 | 18/06/21 (Fri) | 16:10 | GMHBA Stadium | 9.9-63 | Geelong Cats | vs | Footscray Bulldogs | 14.12-96 | View |
| 18/06/21 (Fri) | 19:30 | SkyBus Stadium | 13.15-93 | Frankston | vs | Northern Bullants | 10.4-64 | View | |
| 19/06/21 (Sat) | 12:00 | Arden St - North Melbourne | 11.11-77 | North Melbourne | vs | Coburg | 11.8-74 | View | |
| 19/06/21 (Sat) | 12:00 | Fankhauser Reserve | 24.13-157 | Southport | vs | Brisbane Lions | 7.8-50 | View | |
| 19/06/21 (Sat) | 12:00 | Graham Road, QLD | 18.17-125 | Aspley | vs | Gold Coast Suns | 19.17-131 | View | |
| 19/06/21 (Sat) | 12:05 | Avalon Airport Oval (Chirnside Park) | 15.8-98 | Werribee | vs | GWS Giants | 7.8-50 | View | |
| 19/06/21 (Sat) | 13:00 | ETU Stadium | 10.8-68 | Port Melbourne | vs | Carlton | 12.11-83 | View | |
| 20/06/21 (Sun) | 11:05 | Windy Hill | 7.9-51 | Essendon Bombers | vs | Box Hill Hawks | 15.12-102 | View | |
| 20/06/21 (Sun) | BYE | BYE | Sandringham | ||||||
| 20/06/21 (Sun) | BYE | BYE | Casey Demons | ||||||
| 20/06/21 (Sun) | BYE | BYE | Sydney Swans | ||||||
| 20/06/21 (Sun) | BYE | BYE | Collingwood | ||||||
| 20/06/21 (Sun) | 14:10 | Downer Oval | 11.8-74 | Williamstown | vs | Richmond | 10.14-74 | View | |
| 11 | 25/06/21 (Fri) | 11:35 | South Pine Sport Complex | 8.6-54 | Brisbane Lions | vs | Geelong Cats | 26.16-172 | View |
| 26/06/21 (Sat) | 12:00 | Arden St - North Melbourne | 14.4-88 | North Melbourne | vs | Werribee | 12.11-83 | View | |
| 26/06/21 (Sat) | 12:00 | Highgate Reserve | 7.10-52 | Coburg | vs | Footscray Bulldogs | 13.6-84 | View | |
| 26/06/21 (Sat) | 12:05 | Olympic Park Oval | 16.8-104 | Collingwood | vs | Frankston | 9.11-65 | View | |
| 26/06/21 (Sat) | 13:00 | Box Hill City Oval | 15.19-109 | Box Hill Hawks | vs | Aspley | 7.5-47 | View | |
| 26/06/21 (Sat) | 14:00 | Wilson Storage Trevor Barker Beach Oval | 14.12-96 | Sandringham | vs | Richmond | 10.6-66 | View | |
| 27/06/21 (Sun) | 12:00 | Casey Fields | 13.14-92 | Casey Demons | vs | Essendon Bombers | 6.8-44 | View | |
| 27/06/21 (Sun) | 13:05 | Preston City Oval | 14.16-100 | Northern Bullants | vs | Carlton | 10.8-68 | View | |
| 27/06/21 (Sun) | BYE | BYE | Southport | ||||||
| 27/06/21 (Sun) | BYE | BYE | Gold Coast Suns | ||||||
| 27/06/21 (Sun) | 14:00 | ETU Stadium | 6.14-50 | Port Melbourne | vs | Williamstown | 12.15-87 | View | |
| 27/06/21 (Sun) | 17:45 | Olympic Park Oval | 13.15-93 | GWS Giants | vs | Sydney Swans | 8.7-55 | View | |
| 12 | 02/07/21 (Fri) | 16:10 | GMHBA Stadium | 16.6-102 | Geelong Cats | vs | Essendon Bombers | 3.9-27 | View |
| 03/07/21 (Sat) | 11:00 | Box Hill City Oval | 15.21-111 | Box Hill Hawks | vs | Gold Coast Suns | 5.9-39 | View | |
| 03/07/21 (Sat) | 13:00 | Piranha Park | 15.9-99 | Coburg | vs | Carlton | 9.8-62 | View | |
| 03/07/21 (Sat) | 14:00 | Preston City Oval | 8.7-55 | Northern Bullants | vs | Richmond | 5.12-42 | View | |
| 03/07/21 (Sat) | 19:30 | Casey Fields | 7.12-54 | Casey Demons | vs | GWS Giants | 8.7-55 | View | |
| 04/07/21 (Sun) | 12:00 | Olympic Park Oval | 11.15-81 | Collingwood | vs | Sandringham | 10.3-63 | View | |
| 04/07/21 (Sun) | 12:05 | Victoria University Whitten Oval | 10.7-67 | Footscray Bulldogs | vs | North Melbourne | 8.8-56 | View | |
| 04/07/21 (Sun) | BYE | BYE | Williamstown | ||||||
| 04/07/21 (Sun) | BYE | BYE | Southport | ||||||
| 04/07/21 (Sun) | BYE | BYE | Aspley | ||||||
| 04/07/21 (Sun) | BYE | BYE | Werribee | ||||||
| 04/07/21 (Sun) | BYE | BYE | Port Melbourne | ||||||
| 04/07/21 (Sun) | BYE | BYE | Brisbane Lions | ||||||
| 04/07/21 (Sun) | 18:30 | Avalon Airport Oval (Chirnside Park) | 6.8-44 | Sydney Swans | vs | Frankston | 9.18-72 | View | |
| 13 | 09/07/21 (Fri) | 19:30 | SkyBus Stadium | 18.14-122 | Frankston | vs | Port Melbourne | 4.3-27 | View |
| 10/07/21 (Sat) | 12:00 | Downer Oval | 10.11-71 | Williamstown | vs | Geelong Cats | 12.11-83 | View | |
| 10/07/21 (Sat) | 13:00 | ETU Stadium | 13.15-93 | GWS Giants | vs | Gold Coast Suns | 7.11-53 | View | |
| 10/07/21 (Sat) | 13:05 | Avalon Airport Oval (Chirnside Park) | 7.15-57 | Werribee | vs | Casey Demons | 17.14-116 | View | |
| 11/07/21 (Sun) | BYE | BYE | North Melbourne | ||||||
| 11/07/21 (Sun) | BYE | BYE | Carlton | ||||||
| 11/07/21 (Sun) | BYE | BYE | Box Hill Hawks | ||||||
| 11/07/21 (Sun) | BYE | BYE | Aspley | ||||||
| 11/07/21 (Sun) | 11:05 | Victoria University Whitten Oval | 11.18-84 | Footscray Bulldogs | vs | Sydney Swans | 11.11-77 | View | |
| 11/07/21 (Sun) | 12:00 | Swinburne Centre | 15.11-101 | Richmond | vs | Collingwood | 16.10-106 | View | |
| 11/07/21 (Sun) | 12:05 | Fankhauser Reserve | 20.15-135 | Southport | vs | Brisbane Lions | 2.14-26 | View | |
| 11/07/21 (Sun) | 13:00 | Piranha Park | 12.10-82 | Coburg | vs | Northern Bullants | 12.11-83 | View | |
| 11/07/21 (Sun) | 14:00 | Wilson Storage Trevor Barker Beach Oval | 21.11-137 | Sandringham | vs | Essendon Bombers | 10.10-70 | View | |
| 14 | 16/07/21 (Fri) | 19:30 | SkyBus Stadium | Frankston | vs | Sandringham | View | ||
| 17/07/21 (Sat) | 12:00 | Graham Road, QLD | Aspley | vs | Southport | View | |||
| 17/07/21 (Sat) | 13:05 | Piranha Park | Coburg | vs | Geelong Cats | View | |||
| 17/07/21 (Sat) | 14:00 | ETU Stadium | Port Melbourne | vs | Werribee | View | |||
| 18/07/21 (Sun) | BYE | BYE | Richmond | ||||||
| 18/07/21 (Sun) | BYE | BYE | Footscray Bulldogs | ||||||
| 18/07/21 (Sun) | BYE | BYE | GWS Giants | ||||||
| 18/07/21 (Sun) | BYE | BYE | Sydney Swans | ||||||
| 18/07/21 (Sun) | BYE | BYE | Gold Coast Suns | ||||||
| 18/07/21 (Sun) | BYE | BYE | Brisbane Lions | ||||||
| 18/07/21 (Sun) | 11:05 | IKON Park | Carlton | vs | Collingwood | View | |||
| 18/07/21 (Sun) | 12:00 | Casey Fields | Casey Demons | vs | Box Hill Hawks | View | |||
| 18/07/21 (Sun) | 13:00 | Preston City Oval | Northern Bullants | vs | Williamstown | View | |||
| 18/07/21 (Sun) | 14:05 | Arden St - North Melbourne | North Melbourne | vs | Essendon Bombers | View | |||
| 15 | 24/07/21 (Sat) | BYE | BYE | Footscray Bulldogs | |||||
| 24/07/21 (Sat) | BYE | BYE | Northern Bullants | ||||||
| 24/07/21 (Sat) | BYE | BYE | North Melbourne | ||||||
| 24/07/21 (Sat) | BYE | BYE | Sandringham | ||||||
| 24/07/21 (Sat) | BYE | BYE | Collingwood | ||||||
| 24/07/21 (Sat) | BYE | BYE | Carlton | ||||||
| 24/07/21 (Sat) | BYE | BYE | Casey Demons | ||||||
| 24/07/21 (Sat) | BYE | BYE | Frankston | ||||||
| 24/07/21 (Sat) | BYE | BYE | Geelong Cats | ||||||
| 24/07/21 (Sat) | BYE | BYE | Coburg | ||||||
| 24/07/21 (Sat) | BYE | BYE | Box Hill Hawks | ||||||
| 24/07/21 (Sat) | BYE | BYE | Williamstown | ||||||
| 24/07/21 (Sat) | BYE | BYE | Werribee | ||||||
| 24/07/21 (Sat) | BYE | BYE | Richmond | ||||||
| 24/07/21 (Sat) | BYE | BYE | Sydney Swans | ||||||
| 24/07/21 (Sat) | BYE | BYE | Port Melbourne | ||||||
| 24/07/21 (Sat) | 11:05 | Graham Road, QLD | 6.8-44 | Aspley | vs | Gold Coast Suns | 19.8-122 | View | |
| 25/07/21 (Sun) | 12:05 | Fankhauser Reserve | 11.9-75 | Southport | vs | Essendon Bombers | 10.11-71 | View | |
| 25/07/21 (Sun) | 12:30 | Council Training Oval - Metricon Stadium | 11.20-86 | GWS Giants | vs | Brisbane Lions | 8.11-59 | View | |
| 16 | 31/07/21 (Sat) | 10:30 | Council Training Oval - Metricon Stadium | Gold Coast Suns | vs | Southport | View | ||
| 31/07/21 (Sat) | 12:00 | Arden St - North Melbourne | 11.11-77 | North Melbourne | vs | Port Melbourne | 8.12-60 | View | |
| 31/07/21 (Sat) | 12:00 | Wilson Storage Trevor Barker Beach Oval | 9.6-60 | Sandringham | vs | Carlton | 14.25-109 | View | |
| 31/07/21 (Sat) | 12:05 | Olympic Park Oval | 9.6-60 | Collingwood | vs | Box Hill Hawks | 18.15-123 | View | |
| 31/07/21 (Sat) | 12:30 | Graham Road, QLD | Aspley | vs | Essendon Bombers | View | |||
| 31/07/21 (Sat) | 13:05 | Casey Fields | 10.9-69 | Casey Demons | vs | Footscray Bulldogs | 16.10-106 | View | |
| 31/07/21 (Sat) | 13:30 | South Pine Sport Complex | Brisbane Lions | vs | Sydney Swans | View | |||
| 31/07/21 (Sat) | 14:00 | Preston City Oval | 10.11-71 | Northern Bullants | vs | Werribee | 14.17-101 | View | |
| 01/08/21 (Sun) | BYE | BYE | GWS Giants | ||||||
| 01/08/21 (Sun) | BYE | BYE | Geelong Cats | ||||||
| 01/08/21 (Sun) | 14:00 | Piranha Park | 9.15-69 | Coburg | vs | Williamstown | 10.13-73 | View | |
| 01/08/21 (Sun) | 14:05 | SkyBus Stadium | 12.11-83 | Frankston | vs | Richmond | 15.9-99 | View | |
| 17 | 07/08/21 (Sat) | 10:30 | IKON Park | Carlton | vs | Williamstown | View | ||
| 07/08/21 (Sat) | 13:00 | ETU Stadium | Port Melbourne | vs | Collingwood | View | |||
| 07/08/21 (Sat) | 13:00 | Piranha Park | Coburg | vs | Sandringham | View | |||
| 07/08/21 (Sat) | 13:05 | Swinburne Centre | Richmond | vs | North Melbourne | View | |||
| 07/08/21 (Sat) | 14:05 | Avalon Airport Oval (Chirnside Park) | Werribee | vs | Geelong Cats | View | |||
| 08/08/21 (Sun) | 12:05 | Casey Fields | Casey Demons | vs | Northern Bullants | View | |||
| 08/08/21 (Sun) | BYE | BYE | Frankston | ||||||
| 08/08/21 (Sun) | BYE | BYE | Essendon Bombers | ||||||
| 08/08/21 (Sun) | BYE | BYE | Gold Coast Suns | ||||||
| 08/08/21 (Sun) | BYE | BYE | GWS Giants | ||||||
| 08/08/21 (Sun) | BYE | BYE | Southport | ||||||
| 08/08/21 (Sun) | BYE | BYE | Brisbane Lions | ||||||
| 08/08/21 (Sun) | BYE | BYE | Box Hill Hawks | ||||||
| 08/08/21 (Sun) | BYE | BYE | Footscray Bulldogs | ||||||
| 08/08/21 (Sun) | BYE | BYE | Aspley | ||||||
| 08/08/21 (Sun) | BYE | BYE | Sydney Swans | ||||||
| 18 | 14/08/21 (Sat) | 14:00 | Box Hill City Oval | Box Hill Hawks | vs | Brisbane Lions | View | ||
| 14/08/21 (Sat) | 14:00 | Casey Fields | Casey Demons | vs | Sydney Swans | View | |||
| 14/08/21 (Sat) | 14:00 | GMHBA Stadium | Geelong Cats | vs | Richmond | View | |||
| 14/08/21 (Sat) | 14:00 | IKON Park | Carlton | vs | Aspley | View | |||
| 14/08/21 (Sat) | 14:00 | Piranha Park | Coburg | vs | Southport | View | |||
| 14/08/21 (Sat) | 14:00 | SkyBus Stadium | Frankston | vs | Sandringham | View | |||
| 14/08/21 (Sat) | 14:00 | T.B.A. | GWS Giants | vs | North Melbourne | View | |||
| 14/08/21 (Sat) | 14:00 | T.B.A. | Gold Coast Suns | vs | Port Melbourne | View | |||
| 14/08/21 (Sat) | 14:00 | Victoria Park | Collingwood | vs | Northern Bullants | View | |||
| 14/08/21 (Sat) | 14:00 | Victoria University Whitten Oval | Footscray Bulldogs | vs | Werribee | View | |||
| 14/08/21 (Sat) | 14:00 | Windy Hill | Essendon Bombers | vs | Williamstown | View | |||
| 19 | 21/08/21 (Sat) | 14:00 | Box Hill City Oval | Box Hill Hawks | vs | Aspley | View | ||
| 21/08/21 (Sat) | 14:00 | Casey Fields | Casey Demons | vs | Northern Bullants | View | |||
| 21/08/21 (Sat) | 14:00 | GMHBA Stadium | Geelong Cats | vs | North Melbourne | View | |||
| 21/08/21 (Sat) | 14:00 | IKON Park | Carlton | vs | Southport | View | |||
| 21/08/21 (Sat) | 14:00 | Piranha Park | Coburg | vs | Williamstown | View | |||
| 21/08/21 (Sat) | 14:00 | SkyBus Stadium | Frankston | vs | Port Melbourne | View | |||
| 21/08/21 (Sat) | 14:00 | T.B.A. | Gold Coast Suns | vs | GWS Giants | View | |||
| 21/08/21 (Sat) | 14:00 | T.B.A. | Brisbane Lions | vs | Sydney Swans | View | |||
| 21/08/21 (Sat) | 14:00 | Victoria Park | Collingwood | vs | Werribee | View | |||
| 21/08/21 (Sat) | 14:00 | Victoria University Whitten Oval | Footscray Bulldogs | vs | Richmond | View | |||
| 21/08/21 (Sat) | 14:00 | Windy Hill | Essendon Bombers | vs | Sandringham | View |
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